Predicting the impact of mutations on kinase-substrate phosphorylation
Predicting loss and gain of phosphorylation
MIMP characterizes genetic variants such as cancer mutations that specifically alter kinase-binding sites in proteins. As these residues are changed in disease mutations, alterations in kinase binding specificity potentially lead to rewiring of kinase-substrate interaction networks
Comprehensive kinase-substrate data
MIMP makes use of phosphorylation data for a wide range of kinases to comprehensively predict kinase-rewiring mutations. Kinase specificity models are refined to remove sequences not matching the general motif and improve prediction power.